Active Estrogen–Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells

Uterine endometrial cancer (UEC) is an estrogen-related tumor. Succinate and heme metabolism play important roles in the progression of multiple tumors. However, relationship between estrogen, succinate, related regulatory mechanisms remain largely unknown. In this study, we observed that expression aminolevulinate delta synthase 1 (ALAS1) solute carrier family member 38 (SLC25A38) UEC tissues significantly higher than normal tissues. Further analysis showed estrogen succinate increased ALAS1 SLC25A38 uterine cells (UECC), administration upregulated level receptor (ER). Silencing nuclear coactivator (NCOA1) reversed effects via downregulation expression. Additionally, exposure UECC to cell viability invasiveness, while silencing NCOA1 gene weakened effect. These findings revealed can synergistically increase ERβ/NCOA1 axis, promoting accumulation increasing proliferative invasive potential UECC.